AM I NEXT? NO LOVE AT PACIFIC BIOSCIENCES OF CALIFORNIA

Menlo Park, California-based Pacific Biosciences of California, a biosciences technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems, has announced a restructuring, including a cost-cutting initiative and the closure of its 74,000-square-foot San Diego, California facility.

The cost-cutting initiative and office closure will impact 195 employees, including 71 in the company's Menlo Park office and 108 in the San Diego office. The nearly 25% reduction in force affects nearly all functions within the company, including engineers, scientists, and management-level positions such as directors and vice president.

The scheduled separation date is June 28, 2024. To lower production costs, some consumables manufacturing for reagents and flow cells were previously transferred from San Diego to Menlo Park.

CEO Christian Henry noted, “We believe that the sales cycle increased primarily because of uncertainty surrounding the timing of funding for new capital equipment, particularly in the United States and China. There’s no doubt that PacBio and our industry are facing increasing headwinds this year. However, we remain incredibly optimistic about our business and the prospects for long-read sequencing.

"This swift and decisive action is a demonstration of our plan to achieve positive cash flows by the end of 2026, as originally outlined in our long-term guidance. We remain highly encouraged by PacBio’s long-term growth potential.”

According to a company spokesperson, "The company had to make difficult but necessary changes in response to headwinds that have affected our industry and our performance ... We considered every option and ultimately determined that this is the path we must take to achieve our mission and enable PacBio to drive long-term value creation.”

Change is coming. There will always be a tomorrow, no matter how much you may try to ignore it. There are no guarantees in life or promises for a bright future. We see good people being laid off through no fault of their own. Just because something bad hasn't happened yet doesn't mean it won't. It can happen to anyone, anytime, anywhere. No one is guaranteed to wake up tomorrow and still have a job by evening. Are you now wondering, Am I Next?

AM I NEXT? NO LOVE AT EXELIXIS

Alameda, California-based Exelixis, a biotechnology company focusing on genomics-based drug discovery, has announced a restructuring and a 13% reduction in the company’s workforce.

The restructuring will impact 175 employees and is due to be completed this Quarter. It is believed the changes are being driven by Farallon Capital Management, an activist investor dissatisfied with the company's performance.

Farallon noted, “With the cost of capital increasing and biotech companies of all sizes making hard investment choices regarding compounds to advance and trials to conduct, Exelixis stands out as a company with neither a coherent R&D strategy nor a disciplined approach to spending. Instead of becoming more focused and disciplined, Exelixis is doing precisely the opposite, sponsoring nearly 80 trials simultaneously. We fear the company is spread too thin and lacks expertise across its many different trials.”

According to CEO Michael Morrissey...

“Rebalancing our investment priorities” means Exelixis can focus on label expansions for the approved cancer drug Cabometyx, as well as pushing ahead with the development of zanzalintinib, a tyrosine kinase inhibitor that’s in late-stage studies for colorectal cancer and renal cell carcinoma. Also on the agenda is the phase 1 trial of an antibody-drug conjugate for various solid tumors and a phase 1 USP1 inhibitor recently licensed from Insilico Medicine that’s being developed to treat tumors that have become refractory to PARP inhibitors. And to move three promising preclinical programs into clinical development.”

“We are taking these steps with the conviction that they are necessary for our continued progress toward the company’s goal of delivering an innovative pipeline of biotherapeutics and small molecules to help patients with cancer and create value for all of our stakeholders,” Morrissey added in the preliminary 2023 financial results.

Change is coming. There will always be a tomorrow, no matter how much you may try to ignore it. There are no guarantees in life or promises for a bright future. We see good people being laid off through no fault of their own. Just because something bad hasn't happened yet doesn't mean it won't. It can happen to anyone, anytime, anywhere. No one is guaranteed to wake up tomorrow and still have a job by evening. Are you now wondering, Am I Next?

AM I NEXT? NO LOVE AT AMGEN HORIZON THERAPEUTICS

Lake Forest, Illinois-based Horizon Therapeutics, now owned by Thousand Oaks, California-based Amgen, plans a reduction in force that mainly affects recently acquired Horizon Therapeutics.

The reduction in force will impact 350 former Horizon employees, mostly located in Deerfield, Illinois, with separations beginning on December 30, 2023, and continuing through December 2024.

According to an Amgen spokesperson, "The vast majority of legacy Horizon employees in the U.S. (greater than 80%) are being placed in Amgen roles. reflecting the knowledge and capabilities we need to continue serving patients suffering from rare diseases. We do not take these decisions lightly, and we appreciate the contributions of those employees being impacted. We will treat them with respect and offer support through the process.”

Regarding Horizon's Deerfield offices, "Over time, we will evaluate how these buildings and locations fit into Amgen’s global footprint. Once that process is complete, we will make decisions on whether adjustments to our local footprint are warranted."

Change is coming. There will always be a tomorrow, no matter how much you may try to ignore it. There are no guarantees in life or promises for a bright future. We see good people being laid off through no fault of their own. Just because something bad hasn't happened yet, doesn't mean it won't. It can happen to anyone, anytime, anywhere. No one is guaranteed to wake up tomorrow and still have a job by evening. Are you now wondering, Am I Next?